The role of flow cytometry in the diagnosis of myelodysplastic syndromes

Haema 2011; 2(2): 193-204

by Μarina Κarakantza1, Aikaterini Psarra2

1Haematology Department of University Hospital, Medical School, Patras, 2Department of Immunology – Histocompatibility, Evangelismos, Αthens

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Abstract

The diagnosis of Myelodysplastic syndromes (MDS) relies mainly on the morphology of cells in peripheral blood and bone marrow smears. Despite the extensive research in the pathogenesis of the syndromes and the accumulation of data from various biomedical fields, most of them are not yet incorporated in the diagnostic and prognostic systems of MDS. Data from flow cytometry show that the expression of antigens in patients with MDS differs from that of normal individuals and that they express characteristic patterns in all stages of cellular differentiation. The correlation of these antigenic patterns to other diagnostic parameters or the pathogenetic mechanisms underlying the syndromes is still under investigation.