{"id":1217,"date":"2018-07-15T11:03:07","date_gmt":"2018-07-15T11:03:07","guid":{"rendered":"https:\/\/haema-journal.gr\/?p=1217"},"modified":"2018-07-15T11:03:07","modified_gmt":"2018-07-15T11:03:07","slug":"pathology-and-genetics-classification-of-aggressive-b-cell-lymphomas","status":"publish","type":"post","link":"https:\/\/haema-journal.gr\/?p=1217","title":{"rendered":"Pathology and Genetics classification of aggressive B cell lymphomas"},"content":{"rendered":"<p style=\"text-align: right;\"><em>Haema 2017; 8(1): 9-17<\/em><\/p>\n<p>by A. Papanikolaou, A. Tasidou<\/p>\n<p>Haemopathological Laboratory, Evangelismos General Hospital, Athens, Greece<\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/haema-journal.gr\/PDF\/2017\/HAEMA_2017-9.pdf\" target=\"_blank\" rel=\"noopener\">Full PDF (in Greek)<\/a> | <a href=\"https:\/\/haema-journal.gr\/PDF\/2017\/HAEMA_2017-9.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-390 size-full\" src=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2018\/02\/PDF-icon.jpg\" alt=\"\" width=\"36\" height=\"36\" \/><\/a><\/p>\n<p><!--more--><\/p>\n<h5><strong>Abstract<\/strong><\/h5>\n<p style=\"text-align: justify;\">Aggressive B cell lymphomas is the most common type of non-Hodgkin lymphoma and is a heterogeneous group of lymphomas with different clinical, histological and genetic features. \u03a4he abundance of information that has been gained in recent years regarding the genetic and molecular landscape and its clinical extensions, led to a better understanding of the pathogenesis and the differentiation pathways of the aggressive B cell lymphomas \u201cCell of Origin (COO)\u201d. The COO as well as the repeated mutations that activate multiple oncogenes (double hit status) are capable of standardizing more aggressive forms that are resistant to conventional therapies. Eight years after the WHO\u2019s classification in 2008, the need to incorporate all this information led to its revision and its renewed publication in 2016. This new publication is an update of the 2008 classification\u2019s data of the existing, well defined entities and it also adds a number of proposed entities. The recognition of homogenous and well defined entities remains as the classification\u2019s goal, as well as the facilitation to identify less frequent entities with peculiarities that demand further study.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Haema 2017; 8(1): 9-17 by A. Papanikolaou, A. Tasidou Haemopathological Laboratory, Evangelismos General Hospital, Athens, Greece Full PDF (in Greek) |<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59],"tags":[],"class_list":["post-1217","post","type-post","status-publish","format-standard","hentry","category-haema-2017-1"],"_links":{"self":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1217"}],"version-history":[{"count":1,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1217\/revisions"}],"predecessor-version":[{"id":1218,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1217\/revisions\/1218"}],"wp:attachment":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}