{"id":1234,"date":"2018-07-15T20:48:18","date_gmt":"2018-07-15T20:48:18","guid":{"rendered":"https:\/\/haema-journal.gr\/?p=1234"},"modified":"2018-07-15T20:48:18","modified_gmt":"2018-07-15T20:48:18","slug":"rare-aggressive-b-cell-lymphomas","status":"publish","type":"post","link":"https:\/\/haema-journal.gr\/?p=1234","title":{"rendered":"Rare aggressive B-cell lymphomas"},"content":{"rendered":"<p style=\"text-align: right;\"><em>Haema 2017; 8(1): 95-108<\/em><\/p>\n<p>by Maria K. Angelopoulou, Pantelis Tsirkinidis, Theodoros Vasilakopoulos<\/p>\n<p>National and Kapodistrian University of Athens, Department of Hematology and Bone Marrow Transplantation, Athens, Greece<\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/haema-journal.gr\/PDF\/2017\/HAEMA_2017-95.pdf\" target=\"_blank\" rel=\"noopener\">Full PDF (in Greek)<\/a> | <a href=\"https:\/\/haema-journal.gr\/PDF\/2017\/HAEMA_2017-95.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-390 size-full\" src=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2018\/02\/PDF-icon.jpg\" alt=\"\" width=\"36\" height=\"36\" \/><\/a><\/p>\n<p><!--more--><\/p>\n<h5><strong>Abstract<\/strong><\/h5>\n<p style=\"text-align: justify;\">Within the aggressive B-cell lymphomas, some extremely rare entities have been described, including DLBCL associated with chronic inflammation, lymphomatoid granulomatosis, intravascular large B cell lymphoma, ALK-positive large B cell lymphoma, plasmablastic lymphoma, large cell lymphoma arising in HHV8-associated multicentric Castleman disease and primary effusion lymphoma. The vast majority of these lymphomas present with extranodal disease. At least four of these entities (ALKpositive large B cell lymphoma, plasmablastic lymphoma, large cell lymphoma arising in HHV8-associated multicentric Castleman disease and primary effusion lymphoma) are characterized by plasmablastic morphology and immunophenotype of the neoplastic cells. A common feature of these distinct entities is the presence of acquired immunodeficiency (e.g. HIV infection) with the exception of intravascular and ALK+ large B cell lymphomas. The immunodeficiency status leads to loss of immunosurveillance and allows two gamma herpes virus, namely EBV and HHV-8 to promote lymphomagenesis. More specifically, EBV relates pathogenetically with DLBCL associated with chronic inflammation, lymphomatoid granulomatosis and plasmablastic lymphoma, whereas HHV-8 is linked to large cell lymphoma arising in HHV8-associated multicentric Castleman disease and primary effusion lymphoma. These aggressive rare B cell lymphomas are characterized by poor prognosis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Haema 2017; 8(1): 95-108 by Maria K. Angelopoulou, Pantelis Tsirkinidis, Theodoros Vasilakopoulos National and Kapodistrian University of Athens, Department of Hematology and Bone Marrow Transplantation, Athens, Greece Full PDF (in Greek) |<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59],"tags":[],"class_list":["post-1234","post","type-post","status-publish","format-standard","hentry","category-haema-2017-1"],"_links":{"self":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1234"}],"version-history":[{"count":1,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1234\/revisions"}],"predecessor-version":[{"id":1235,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1234\/revisions\/1235"}],"wp:attachment":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}