{"id":1238,"date":"2018-07-15T20:55:19","date_gmt":"2018-07-15T20:55:19","guid":{"rendered":"https:\/\/haema-journal.gr\/?p=1238"},"modified":"2018-07-15T20:55:19","modified_gmt":"2018-07-15T20:55:19","slug":"leukemic-stem-cells","status":"publish","type":"post","link":"https:\/\/haema-journal.gr\/?p=1238","title":{"rendered":"Leukemic stem cells"},"content":{"rendered":"<p style=\"text-align: right;\"><em>Haema 2017; 8(2): 130-135<\/em><\/p>\n<p>by Konstantia Pavlaki, Haralampos Pontikoglou<\/p>\n<p>Haemopoiesis Research Laboratory, Haematology Department, School of Medicine University of Crete, Greece<\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/haema-journal.gr\/PDF\/2017\/HAEMA_2017-130.pdf\" target=\"_blank\" rel=\"noopener\">Full PDF (in Greek)<\/a> | <a href=\"https:\/\/haema-journal.gr\/PDF\/2017\/HAEMA_2017-130.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-390 size-full\" src=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2018\/02\/PDF-icon.jpg\" alt=\"\" width=\"36\" height=\"36\" \/><\/a><\/p>\n<p><!--more--><\/p>\n<h5><strong>Abstract<\/strong><\/h5>\n<p style=\"text-align: justify;\">Leukemic stem cells (LSCs) represent a subpopulation of leukemic cells that are capable of generating and perpetuating disease. In the present review, various cellular and molecular characteristics of LSCs that play a major role in their survival will be discussed, including intrinsic signaling pathways and extrinsic microenvironmental cues. Dynamic interactions between LSCs and microenvironment components resulting in the former evading chemotherapy-induced death and acquiring a drugresistant phenotype will be outlined and potential targeted therapies specifically designed to disrupt the complex interplay between the leukemic niche and LSCs will be described.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Haema 2017; 8(2): 130-135 by Konstantia Pavlaki, Haralampos Pontikoglou Haemopoiesis Research Laboratory, Haematology Department, School of Medicine University of Crete, Greece Full PDF (in Greek) |<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[60],"tags":[],"class_list":["post-1238","post","type-post","status-publish","format-standard","hentry","category-haema-2017-2"],"_links":{"self":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1238","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1238"}],"version-history":[{"count":1,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1238\/revisions"}],"predecessor-version":[{"id":1239,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1238\/revisions\/1239"}],"wp:attachment":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1238"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1238"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1238"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}