{"id":1244,"date":"2018-07-15T21:18:49","date_gmt":"2018-07-15T21:18:49","guid":{"rendered":"https:\/\/haema-journal.gr\/?p=1244"},"modified":"2018-07-15T21:18:49","modified_gmt":"2018-07-15T21:18:49","slug":"induction-and-post-remission-treatment-of-acute-myeloid-leukemia","status":"publish","type":"post","link":"https:\/\/haema-journal.gr\/?p=1244","title":{"rendered":"Induction and Post-Remission Treatment of Acute Myeloid Leukemia"},"content":{"rendered":"<p style=\"text-align: right;\"><em>Haema 2017; 8(2): 168-178<\/em><\/p>\n<p>by Anastasia Skandali<sup>1<\/sup>, Panagiotis Tsirigotis<sup>2<\/sup><\/p>\n<p><sup>1<\/sup>Hematologist, Head, Department of Haematology, \u201cHygeia\u201d Hospital, Athens, Greece,<br \/>\n<sup>2<\/sup>Assistant Professor of Hematology, National and Kapodistrian University of Athens, 2nd Department of Propedeutic Internal Medicine, \u201cAttikon\u201d University General Hospital, Athens, Greece<\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/haema-journal.gr\/PDF\/2017\/HAEMA_2017-168.pdf\" target=\"_blank\" rel=\"noopener\">Full PDF (in Greek)<\/a> | <a href=\"https:\/\/haema-journal.gr\/PDF\/2017\/HAEMA_2017-168.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-390 size-full\" src=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2018\/02\/PDF-icon.jpg\" alt=\"\" width=\"36\" height=\"36\" \/><\/a><\/p>\n<p><!--more--><\/p>\n<h5><strong>Abstract<\/strong><\/h5>\n<p style=\"text-align: justify;\">Despite considerable progress in our understanding of the genetic heterogeneity and the molecular pathogenesis of acute myeloid leukemia (AML), the identification of prognostic factors, and the rapidly increased treatment options, the overall outcome of AML patients remains unsatisfactory, particularly for the patients older than 60-65 years. Although some improvement during the last 4 decades is apparent among younger patients, still only ~35% of such patients entered on clinical trials are cured of their disease. The majority of AML patients succumb to their disease primarily due to resistance to treatment or to relapse of the disease. Over several decades our approach to the first step of treatment (induction therapy) has largely remained the same, but our approach to the second step (postremission therapy) has evolved significantly. The prospect for durable disease control with the offer of intensified chemotherapy or with hematopoietic stem cell transplantation is based on the identification of biologic markers present at diagnosis before treatment and the characterization of minimal residual treatment after induction therapy. Insights gathered incrementally from research have allowed tailoring treatment and avoid the \u201cone size fits all\u201d approach. New treatment strategies generate genuine excitement about the future.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Haema 2017; 8(2): 168-178 by Anastasia Skandali1, Panagiotis Tsirigotis2 1Hematologist, Head, Department of Haematology, \u201cHygeia\u201d Hospital, Athens, Greece, 2Assistant Professor of Hematology, National and Kapodistrian University of Athens, 2nd Department of Propedeutic Internal Medicine, \u201cAttikon\u201d University General Hospital, Athens, Greece Full PDF (in Greek) |<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[60],"tags":[],"class_list":["post-1244","post","type-post","status-publish","format-standard","hentry","category-haema-2017-2"],"_links":{"self":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1244"}],"version-history":[{"count":1,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1244\/revisions"}],"predecessor-version":[{"id":1245,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/1244\/revisions\/1245"}],"wp:attachment":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1244"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1244"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}