{"id":2030,"date":"2025-12-24T13:30:36","date_gmt":"2025-12-24T13:30:36","guid":{"rendered":"https:\/\/haema-journal.gr\/?p=2030"},"modified":"2025-12-24T15:24:44","modified_gmt":"2025-12-24T15:24:44","slug":"%ce%b5%ce%bc%cf%80%cf%8d%cf%81%ce%b5%cf%84%ce%bf-%cf%83%ce%ae%cf%88%ce%b7-%cf%83%ce%b5-%ce%b1%cf%83%ce%b8%ce%b5%ce%bd%ce%ae-%ce%bc%ce%b5-%ce%b1%ce%b9%ce%bc%ce%bf%cf%83%cf%86%ce%b1%ce%b9%cf%81%ce%b9","status":"publish","type":"post","link":"https:\/\/haema-journal.gr\/?p=2030","title":{"rendered":"\u0395\u03bc\u03c0\u03cd\u03c1\u03b5\u03c4\u03bf-\u03a3\u03ae\u03c8\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b1"},"content":{"rendered":"<p style=\"text-align: right;\"><em>Haema 2025; 16(1):30-33<\/em><\/p>\n<p>\u0391\u03bc\u03b1\u03bb\u03af\u03b1 \u0391\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03bf\u03c0\u03bf\u03cd\u03bb\u03bf\u03c5<sup>1<\/sup>, \u039c\u03b1\u03c1\u03af\u03b1 \u0394\u03b7\u03bc\u03bf\u03c0\u03bf\u03cd\u03bb\u03bf\u03c5<sup>2<\/sup><\/p>\n<p><sup>1<\/sup>\u0391\u0384 \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b7\u03c2 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03a3\u03c7\u03bf\u03bb\u03ae\u03c2 \u03c4\u03bf\u03c5 \u0395.\u039a.\u03a0.\u0391. \u0393\u039d\u0391 \u00ab\u039b\u03b1\u03ca\u03ba\u03cc\u00bb<br \/>\n<sup>2<\/sup>\u039c\u03bf\u03bd\u03ac\u03b4\u03b1 \u039c\u03b5\u03c3\u03bf\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u0391\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2, \u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u0395\u03bc\u03c0\u03b5\u03b9\u03c1\u03bf\u03b3\u03bd\u03c9\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2 \u03a3\u03c0\u03ac\u03bd\u03b9\u03c9\u03bd \u0391\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd (\u0391\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03bf\u03c0\u03b1\u03b8\u03b5\u03b9\u03ce\u03bd) &amp; \u03a3\u03c0\u03ac\u03bd\u03b9\u03c9\u03bd \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03bd.Gaucher \u039d\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u0393\u039d\u0391 \u00ab\u039b\u03b1\u03ca\u03ba\u03cc\u00bb<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: right;\"><a href=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Full PDF<\/a> | <a href=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-390 size-full\" src=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2018\/02\/PDF-icon.jpg\" alt=\"\" width=\"36\" height=\"36\" \/><\/a><\/p>\n<p><!--more--><\/p>\n<p><strong>\u0391\u03bb\u03bb\u03b7\u03bb\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1:<\/strong> \u039c\u03b1\u03c1\u03af\u03b1 \u0394\u03b7\u03bc\u03bf\u03c0\u03bf\u03cd\u03bb\u03bf\u03c5,\u00a0\u039c\u03bf\u03bd\u03ac\u03b4\u03b1 \u039c\u03b5\u03c3\u03bf\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u0391\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2-\u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u0395\u03bc\u03c0\u03b5\u03b9\u03c1\u03bf\u03b3\u03bd\u03c9\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2 \u0391\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03bf\u03c0\u03b1\u03b8\u03b5\u03b9\u03ce\u03bd, \u0393\u039d\u0391 \u00ab\u039b\u03b1\u03ca\u03ba\u03cc\u00bb, E-mail: mdimkma@gmail.com<\/p>\n<hr \/>\n<h5 style=\"text-align: justify;\"><strong>\u0395\u0399\u03a3\u0391\u0393\u03a9\u0393\u0397<\/strong><\/h5>\n<p style=\"text-align: justify;\">\u039f\u03b9 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b1\u03af\u03c4\u03b9\u03bf \u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b8\u03bd\u03b7\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03bf\u03c0\u03ac\u03b8\u03b5\u03b9\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b7 \u03b5\u03ba\u03c0\u03b1\u03af\u03b4\u03b5\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03cc\u03c7\u03c9\u03bd \u03c5\u03c0\u03b7\u03c1\u03b5\u03c3\u03b9\u03ce\u03bd \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b8\u03b1\u03bd\u03b1\u03c4\u03b7\u03c6\u03cc\u03c1\u03c9\u03bd \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03c9\u03bd.<\/p>\n<p style=\"text-align: justify;\"><strong>\u039b\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b8\u03b1\u03bb\u03b1\u03c3\u03c3\u03b1\u03b9\u03bc\u03af\u03b1<\/strong><\/p>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03b7 \u03b8\u03b1\u03bb\u03b1\u03c3\u03c3\u03b1\u03b9\u03bc\u03af\u03b1, \u03b7 \u03bc\u03b7 \u03b1\u03c0\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03ae \u03b5\u03c1\u03c5\u03b8\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03b9\u03bc\u03cc\u03bb\u03c5\u03c3\u03b7, \u03c0\u03bf\u03c5 \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b3\u03b3\u03af\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03c6\u03cc\u03c1\u03c4\u03c9\u03c3\u03b7 \u03bc\u03b5 \u03c3\u03af\u03b4\u03b7\u03c1\u03bf, \u03ad\u03c7\u03bf\u03c5\u03bd \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03c0\u03bf\u03bb\u03bb\u03ce\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c2 \u03bb\u03cc\u03b3\u03bf\u03c2 CD4\/CD8, \u03bf\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03c4\u03b1\u03be\u03af\u03b1\u03c2 \u03c4\u03c9\u03bd \u03bf\u03c5\u03b4\u03b5\u03c4\u03b5\u03c1\u03bf\u03c6\u03af\u03bb\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03bc\u03b1\u03ba\u03c1\u03bf\u03c6\u03ac\u03b3\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c6\u03b1\u03b3\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03c3\u03b7\u03c2, \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c3\u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03c9\u03bd NK \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd, \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd C3 \u03ba\u03b1\u03b9 C4 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03bd\u03bf\u03c3\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u0392- \u03bb\u03b5\u03bc\u03c6\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03bc\u03b5 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03ac\u03c2 \u03c4\u03bf\u03c5\u03c2.<sup>1<\/sup><\/p>\n<p style=\"text-align: justify;\">O\u03b9 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2 \u03c9\u03c2 \u03b5\u03c0\u03af \u03c4\u03bf \u03c0\u03bb\u03b5\u03af\u03c3\u03c4\u03bf\u03bd \u03bf\u03c6\u03b5\u03af\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 gram (-) \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03b7 <em>Klebsiella<\/em><em> pneumoniae<\/em><em>, Escherichia<\/em><em> coli<\/em><em>, Pseudomonas<\/em><em> aeruginosa<\/em><em>, Yersinia<\/em><em> enterocolitica<\/em><em>,<\/em> Salmonella typhi \u03ba.\u03b1., \u03b1\u03bb\u03bb\u03ac \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd Streptococcus pneumoniae.<sup>2,3<\/sup> \u0395\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03b1\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c5\u03c0\u03bf\u03b2\u03bb\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03c3\u03c0\u03bb\u03b7\u03bd\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae (\u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03c9\u03bd \u03b1\u03c0\u03cc \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03b1 \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03ba\u03ac\u03c8\u03b1; <em>Streptococcus<\/em><em> pneumoniae<\/em><em>, Neisseria<\/em><em> meningitides<\/em><em>, Haemophilus<\/em><em> influenza<\/em> type b) \u03ba\u03b1\u03b9 \u03b1\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03b9 \u03b1\u03b9\u03bc\u03bf\u03c3\u03b9\u03b4\u03ae\u03c1\u03c9\u03c3\u03b7 \u03ae \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03c0\u03bf\u03c3\u03b9\u03b4\u03ae\u03c1\u03c9\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03b4\u03b5\u03c3\u03c6\u03b5\u03c1\u03b9\u03bf\u03be\u03b1\u03bc\u03af\u03bd\u03b7 (<em>Yersinia<\/em><em> enterocolitica<\/em><em>, Mucorales<\/em>). \u039f \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03bc\u03b5\u03c4\u03ac\u03b3\u03b3\u03b9\u03c3\u03b7\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 (\u03b9\u03bf\u03af, \u03b2\u03b1\u03ba\u03c4\u03ae\u03c1\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ac\u03c3\u03b9\u03c4\u03b1, \u03cc\u03c0\u03c9\u03c2 <em>plasmodium<\/em> sp) \u03ad\u03c7\u03b5\u03b9 \u03b5\u03bb\u03b1\u03c7\u03b9\u03c3\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03bc\u03b5\u03c4\u03ac \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03b4\u03bf\u03c3\u03b7\u03c2 \u03bb\u03bf\u03b9\u03bc\u03c9\u03b4\u03ce\u03bd \u03bd\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03b3\u03b3\u03b9\u03c3\u03b7.<\/p>\n<p style=\"text-align: justify;\">\u03a0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 10% \u03c4\u03c9\u03bd \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ad\u03c2. \u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c3\u03c0\u03bb\u03b7\u03bd\u03b5\u03ba\u03c4\u03bf\u03bc\u03ae \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1 &gt;10 \u03b5\u03c4\u03ce\u03bd, \u03b7 \u03bb\u03ae\u03c8\u03b7 \u03b4\u03b5\u03c3\u03c6\u03b5\u03c1\u03b9\u03bf\u03be\u03b1\u03bc\u03af\u03bd\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b7 \u03c6\u03b5\u03c1\u03c1\u03b9\u03c4\u03af\u03bd\u03b7 \u03bf\u03c1\u03bf\u03cd &gt;1000ng\/ml.<sup>2,4<\/sup> \u0397 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bc\u03b5 \u03b8\u03b1\u03bb\u03b1\u03c3\u03c3\u03b1\u03b9\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c5\u03c1\u03b5\u03c4\u03cc \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u0391\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf 1.<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1991 alignnone\" src=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f1.jpg\" alt=\"\" width=\"2026\" height=\"1201\" srcset=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f1.jpg 2026w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f1-300x178.jpg 300w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f1-1024x607.jpg 1024w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f1-768x455.jpg 768w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f1-1536x911.jpg 1536w\" sizes=\"auto, (max-width: 2026px) 100vw, 2026px\" \/><\/p>\n<p style=\"text-align: justify;\"><em><strong>\u0391\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf\u03c2 1.<\/strong><\/em> \u0391\u03c1\u03c7\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bc\u03b5 \u03b8\u03b1\u03bb\u03b1\u03c3\u03c3\u03b1\u03b9\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c0\u03cd\u03c1\u03b5\u03c4\u03bf.<\/p>\n<p style=\"text-align: justify;\"><strong>\u039b\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b4\u03c1\u03b5\u03c0\u03b1\u03bd\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1<\/strong><\/p>\n<p style=\"text-align: justify;\">\u03a3\u03c4\u03b7 \u03b4\u03c1\u03b5\u03c0\u03b1\u03bd\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 (\u0394\u0391), \u03bf\u03b9 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b1\u03c0\u03bf\u03c6\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2 (\u0391\u039a) \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b1\u03c3\u03c0\u03bb\u03b7\u03bd\u03af\u03b1 \u03ae\u03b4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03ce\u03c4\u03bf\u03c5\u03c2 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03b6\u03c9\u03ae\u03c2. \u0395\u03c0\u03b9\u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1, \u03b7 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03b9\u03bc\u03cc\u03bb\u03c5\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u0391\u039a \u03bf\u03b4\u03b7\u03b3\u03bf\u03cd\u03bd \u03c3\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ae \u03ba\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03c5\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03bf\u03c3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03c9\u03bd \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03bf\u03c0\u03c5\u03c1\u03ae\u03bd\u03c9\u03bd.<sup>5<\/sup> \u039f\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b9\u03c1\u03c1\u03b5\u03c0\u03b5\u03af\u03c2 \u03c3\u03b5 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03b9\u03c2 \u03b1\u03c0\u03cc \u03b2\u03b1\u03ba\u03c4\u03ae\u03c1\u03b9\u03b1 \u03bc\u03b5 \u03ba\u03ac\u03c8\u03b1 \u03ba\u03b1\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03bb\u03bf\u03b9\u03bc\u03ce\u03be\u03b5\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c2 \u03c3\u03b5 \u03b2\u03c1\u03ad\u03c6\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03b9\u03b4\u03b9\u03ac \u03bc\u03b5 \u03b4\u03c1\u03b5\u03c0\u03b1\u03bd\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b4\u03c1\u03b5\u03c0\u03b1\u03bd\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03bd\u03cc\u03c3\u03bf S\/\u03b20. \u0397 \u03c0\u03b1\u03b8\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03c0\u03cc \u03c4\u03b7 \u03b8\u03b1\u03bb\u03b1\u03c3\u03c3\u03b1\u03b9\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03cc\u03bb\u03bf\u03b9 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c5\u03c0\u03b5\u03c1\u03c6\u03cc\u03c1\u03c4\u03c9\u03c3\u03b7 \u03bc\u03b5 \u03c3\u03af\u03b4\u03b7\u03c1\u03bf.<\/p>\n<p style=\"text-align: justify;\">\u039f\u03b9 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2 \u03c4\u03b7\u03c2 NHLBI (National Heart Lung and Blood Institute) \u03ba\u03b1\u03b9 NIH (National Institutes of Health) \u03c4\u03c9\u03bd \u0397\u03a0\u0391 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03ac\u03bc\u03b5\u03c3\u03b7 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03c3\u03c4\u03bf \u03a4\u03bc\u03ae\u03bc\u03b1 \u0395\u03c0\u03b5\u03b9\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03cc\u03bb\u03c9\u03bd \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03b8\u03b5\u03c1\u03bc\u03bf\u03ba\u03c1\u03b1\u03c3\u03af\u03b1 \u226538.5\u00b0C.<sup>6<\/sup> \u038c\u03bc\u03c9\u03c2 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03af \u03c3\u03c5\u03c3\u03c4\u03ae\u03bd\u03bf\u03c5\u03bd \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5 \u03bf\u03c1\u03af\u03bf\u03c5, \u03cc\u03c0\u03c9\u03c2 \u226538\u00b0C \u03ae \u226538.3\u00b0C.<sup>7<\/sup> \u03a7\u03c1\u03b5\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03bf\u03c3\u03bf\u03c7\u03ae \u03cc\u03c4\u03b1\u03bd \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03c0\u03c5\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03ae \u03bc\u03b7 \u03c3\u03c4\u03b5\u03c1\u03bf\u03b5\u03b9\u03b4\u03ae \u03b1\u03bd\u03c4\u03b9\u03c6\u03bb\u03b5\u03b3\u03bc\u03bf\u03bd\u03ce\u03b4\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03bf\u03c5 \u03ac\u03bb\u03b3\u03bf\u03c5\u03c2 \u03ae \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03bd\u03bd\u03bf\u03c3\u03b7\u03c1\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1\u03c4\u03af \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bf \u03c0\u03c5\u03c1\u03b5\u03c4\u03cc\u03c2 \u03bd\u03b1 \u03ba\u03b1\u03bb\u03c5\u03c6\u03b8\u03b5\u03af. \u0397 \u03bb\u03ae\u03c8\u03b7 \u03c5\u03b4\u03c1\u03bf\u03be\u03c5\u03bf\u03c5\u03c1\u03af\u03b1\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03c3\u03b5\u03b9 \u03c4\u03b1 \u03bb\u03b5\u03c5\u03ba\u03ac \u03b1\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03af\u03c1\u03b9\u03b1. \u0395\u03c0\u03b9\u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b1, \u03c3\u03c5\u03bd\u03ae\u03b8\u03b5\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c0\u03bb\u03bf\u03ba\u03ad\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03bf\u03be\u03cd \u03b8\u03c9\u03c1\u03b1\u03ba\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf (\u039f\u0398\u03a3) \u03ba\u03b1\u03b9 \u03b7 \u03bf\u03be\u03b5\u03af\u03b1 \u0391\u039a \u03b4\u03b5\u03bd \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03b5\u03cd\u03ba\u03bf\u03bb\u03b1 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03b8\u03bf\u03cd\u03bd \u03b1\u03c0\u03cc \u03c4\u03b7 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03b5\u03bd\u03ce \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c5\u03bd\u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd.<\/p>\n<p style=\"text-align: justify;\">\u0397 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bc\u03b5 \u0394\u0391 \u03ba\u03b1\u03b9 \u03b5\u03bc\u03c0\u03cd\u03c1\u03b5\u03c4\u03bf, \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03cc\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03bc\u03b5 \u03b8\u03b1\u03bb\u03b1\u03c3\u03c3\u03b1\u03b9\u03bc\u03af\u03b1, \u03bd\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc, \u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd \u03b5\u03bd\u03b4\u03b5\u03b9\u03ba\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03ae \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7\u03c2 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03cc\/\u03c0\u03b1\u03c1\u03b1\u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03ba\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03b9\u03c4\u03ae\u03c4\u03c9\u03c2 \u03bc\u03ad\u03c4\u03c1\u03b7\u03c3\u03b7 \u03ba\u03bf\u03c1\u03b5\u03c3\u03bc\u03bf\u03cd sO<sub>2<\/sub>. \u038c\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03bf\u03c5 \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03af\u03bf\u03c5 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03bf\u03ba\u03bf\u03ba\u03ba\u03b9\u03ba\u03ae\u03c2 \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03ae \u039f\u0398\u03a3 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf\u03c2 \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2. \u0397 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae \u03c4\u03b9\u03bc\u03ae \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03c3\u03b9\u03c4\u03bf\u03bd\u03af\u03bd\u03b7\u03c2 \u03bf\u03c1\u03bf\u03cd (&lt;0, &lt;0.6, &lt;1 \u03ae &lt;2 ng\/mL, \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7) \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bc\u03b5 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03c3\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7<sup>10-12<\/sup> \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c6\u03b1\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae \u03ba\u03b1\u03b9 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03af\u03b1 \u03b5\u03c6\u03cc\u03c3\u03bf\u03bd \u03c0\u03bb\u03b7\u03c1\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2.<\/p>\n<p style=\"text-align: justify;\">\u038c\u03bb\u03bf\u03b9 \u03bf\u03b9 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u0394\u0391 \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c0\u03c5\u03c1\u03b5\u03c4\u03cc \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03c3\u03c4\u03bf \u03a4\u03bc\u03ae\u03bc\u03b1 \u0395\u03c0\u03b5\u03b9\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03a0\u03b5\u03c1\u03b9\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd. \u039f \u03b1\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf\u03c2 2 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7. \u03a7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03cc\u03bb\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03ba\u03b5\u03c6\u03c4\u03c1\u03b9\u03b1\u03be\u03cc\u03bd\u03b7, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03c9\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03ba\u03ac\u03c8\u03b1 \u03ba\u03b1\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b1\u03ba\u03c1\u03cc \u03c7\u03c1\u03cc\u03bd\u03bf \u03b7\u03bc\u03b9\u03b6\u03c9\u03ae\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03c3\u03c4\u03c1\u03ad\u03c8\u03bf\u03c5\u03bd \u03c3\u03c0\u03af\u03c4\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03bc\u03b7\u03b8\u03bf\u03cd\u03bd \u03c4\u03b7\u03bd \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b7\u03bc\u03ad\u03c1\u03b1. \u03a4\u03bf\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b1\u03c6\u03ae\u03c2 \u03b5\u03c3\u03c4\u03af\u03b1 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7\u03c2 (\u03c0\u03c7. \u03bc\u03ad\u03c3\u03b7 \u03c0\u03c5\u03ce\u03b4\u03b7\u03c2 \u03c9\u03c4\u03af\u03c4\u03b9\u03c2), \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03b5\u03b9 \u03b7 \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03c0\u03b1\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1\u03c4\u03af \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03c3\u03b5 \u03b4\u03b9\u03b7\u03b8\u03b7\u03c4\u03b9\u03ba\u03ae \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03cc\u03c2. \u0394\u03b5\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c3\u03b1\u03c6\u03ce\u03c2 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03b5\u03bd\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03bf\u03c3\u03b7\u03bb\u03b5\u03af\u03b1\u03c2. \u039f \u0391\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf\u03c2 3 \u03c3\u03c5\u03bd\u03bf\u03c8\u03af\u03b6\u03b5\u03b9 \u03c4\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03c9\u03bd \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd, \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03c0\u03c1\u03bf \u03c4\u03b7\u03c2 \u03b5\u03c6\u03b1\u03c1\u03bc\u03bf\u03b3\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03bc\u03b2\u03bf\u03bb\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd \u03bc\u03b5 \u03c3\u03c5\u03b6\u03b5\u03c5\u03b3\u03bc\u03ad\u03bd\u03b1 \u03b5\u03bc\u03b2\u03cc\u03bb\u03b9\u03b1 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03bf\u03ba\u03cc\u03ba\u03ba\u03bf\u03c5.<sup>13,14<\/sup> \u0397 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u0391\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf 4. \u03a3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03bf \u03ba\u03b1\u03c4\u03ce\u03c4\u03b5\u03c1\u03bf \u03b1\u03bd\u03b1\u03c0\u03bd\u03b5\u03c5\u03c3\u03c4\u03b9\u03ba\u03cc \u03ae \u03bc\u03b5 \u03b4\u03b9\u03ac\u00ad\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03af\u03b1\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c5\u03c8\u03b7\u03bb\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c5\u03c0\u03bf\u03c8\u03af\u03b1 \u03b3\u03b9\u03b1 \u03bf\u03be\u03cd \u03b8\u03c9\u03c1\u03b1\u03ba\u03b9\u03ba\u03cc \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b7. \u0395\u03ac\u03bd \u03bf \u03ba\u03bf\u03c1\u03b5\u03c3\u03bc\u03cc\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 &lt;94% \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b4\u03b5\u03af\u03b3\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03b1\u03ad\u03c1\u03b9\u03b1 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c5\u03c0\u03bf\u03be\u03c5\u03b3\u03bf\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 \u03bd\u03b1 \u03b4\u03b9\u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b3\u03c1\u03b1\u03c6\u03af\u03b1 \u03b8\u03ce\u03c1\u03b1\u03ba\u03bf\u03c2 \u03ba\u03b1\u03b9 CTPA \u03b3\u03b9\u03b1 \u03b4\u03b9\u03b5\u03c1\u03b5\u03cd\u03bd\u03b7\u03c3\u03b7 \u03bf\u03be\u03ad\u03bf\u03c2 \u03b8\u03c9\u03c1\u03b1\u03ba\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc \u03c0\u03bd\u03b5\u03c5\u03bc\u03bf\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b5\u03bc\u03b2\u03bf\u03bb\u03ae. \u0395\u03ac\u03bd \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b7 \u03c5\u03c0\u03bf\u03be\u03c5\u03b3\u03bf\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03b4\u03b5\u03bd \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03bd\u03c5\u03b4\u03ac\u03c4\u03c9\u03c3\u03b7, \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03bc\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03b1\u03ba\u03ae \u03b1\u03b3\u03c9\u03b3\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03bf\u03be\u03c5\u03b3\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03b5\u03af\u03b3\u03bf\u03c5\u03c3\u03b1 \u03b5\u03ba\u03c4\u03af\u03bc\u03b7\u03c3\u03b7 \u03b1\u03c0\u03cc \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03cc\u03b3\u03bf \u03b3\u03b9\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae \u03ad\u03bd\u03b1\u03c1\u03be\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03bc\u03b5\u03c4\u03b1\u03b3\u03b3\u03af\u03c3\u03b5\u03b9\u03c2\/\u03b1\u03c6\u03b1\u03b9\u03bc\u03b1\u03be\u03bf\u03bc\u03b5\u03c4\u03b1\u03b3\u03b3\u03af\u03c3\u03b5\u03b9\u03c2. \u038c\u03c4\u03b1\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03b1\u03c6\u03ae\u03c2 \u03b5\u03c3\u03c4\u03af\u03b1 \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b2\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03bc\u03b7\u03bd\u03b9\u03b3\u03b3\u03af\u03c4\u03b9\u03b4\u03b1, \u03bb\u03bf\u03af\u03bc\u03c9\u03be\u03b7 \u03bf\u03c5\u03c1\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03ae \u03bf\u03c3\u03c4\u03b5\u03bf\u03bc\u03c5\u03b5\u03bb\u03af\u03c4\u03b9\u03b4\u03b1, \u03b7 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b4\u03b9\u03b1\u03c6\u03ad\u03c1\u03b5\u03b9 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03ae \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u0394\u0391 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b9\u03c2 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03b5\u03c2 \u03bf\u03b4\u03b7\u03b3\u03af\u03b5\u03c2. \u0395\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b1 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ac \u03b5\u03c0\u03b9\u03b4\u03b7\u03bc\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1 \u03bc\u03b9\u03ba\u03c1\u03bf\u03b2\u03b9\u03b1\u03ba\u03ce\u03bd \u03b1\u03bd\u03c4\u03bf\u03c7\u03ce\u03bd. \u0395\u03ac\u03bd \u03bf \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae\u03c2 \u03c6\u03ad\u03c1\u03b5\u03b9 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b3\u03b9\u03b1 \u03c0\u03bf\u03bb\u03c5\u03b1\u03bd\u03b8\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c0\u03b1\u03b8\u03bf\u03b3\u03cc\u03bd\u03b1, \u03c4\u03cc\u03c4\u03b5 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03c9\u03c0\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b2\u03ac\u03c3\u03b5\u03b9 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03c9\u03bd \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03c4\u03ae\u03c1\u03b9\u03c9\u03bd \u03bf\u03b4\u03b7\u03b3\u03b9\u03ce\u03bd.<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1992 alignnone\" src=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f2.jpg\" alt=\"\" width=\"2010\" height=\"1335\" srcset=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f2.jpg 2010w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f2-300x199.jpg 300w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f2-1024x680.jpg 1024w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f2-768x510.jpg 768w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f2-1536x1020.jpg 1536w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f2-272x182.jpg 272w\" sizes=\"auto, (max-width: 2010px) 100vw, 2010px\" \/><\/p>\n<p style=\"text-align: justify;\"><em><strong>\u0391\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf\u03c2 2.<\/strong><\/em> \u0391\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf\u03c2 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bc\u03b5 \u03b4\u03c1\u03b5\u03c0\u03b1\u03bd\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03c5\u03c1\u03b5\u03c4\u03cc.<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1993 alignnone\" src=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f3.jpg\" alt=\"\" width=\"2023\" height=\"1479\" srcset=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f3.jpg 2023w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f3-300x219.jpg 300w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f3-1024x749.jpg 1024w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f3-768x561.jpg 768w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f3-1536x1123.jpg 1536w\" sizes=\"auto, (max-width: 2023px) 100vw, 2023px\" \/><\/p>\n<p style=\"text-align: justify;\"><em><strong>\u0391\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf\u03c2 3.<\/strong><\/em> \u039a\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b5\u03b9\u03c3\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03bc\u03b5 \u0394\u03c1\u03b5\u03c0\u03b1\u03bd\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u039d\u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03c0\u03c5\u03c1\u03b5\u03c4\u03cc \u03c3\u03c4\u03bf \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf.<\/p>\n<p style=\"text-align: justify;\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1994 alignnone\" src=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f4.jpg\" alt=\"\" width=\"2023\" height=\"1060\" srcset=\"https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f4.jpg 2023w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f4-300x157.jpg 300w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f4-1024x537.jpg 1024w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f4-768x402.jpg 768w, https:\/\/haema-journal.gr\/wp-content\/uploads\/2025\/12\/Haema-16-30-f4-1536x805.jpg 1536w\" sizes=\"auto, (max-width: 2023px) 100vw, 2023px\" \/><\/p>\n<p style=\"text-align: justify;\"><em><strong>\u0391\u03bb\u03b3\u03cc\u03c1\u03b9\u03b8\u03bc\u03bf\u03c2 4.<\/strong><\/em> \u0395\u03bd\u03b4\u03bf\u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03b9\u03b1\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03b5\u03bc\u03c0\u03c5\u03c1\u03ad\u03c4\u03bf\u03c5 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03bc\u03b5 \u0394\u03c1\u03b5\u03c0\u03b1\u03bd\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u039d\u03cc\u03c3\u03bf.<\/p>\n<h5 style=\"text-align: justify;\"><strong>\u0392\u0399\u0392\u039b\u0399\u039f\u0393\u03a1\u0391\u03a6\u0399\u0391<\/strong><\/h5>\n<ol>\n<li style=\"text-align: justify;\">Vento S, Cainelli F, Cesario F. Infections in thalassemia. Lancet Infect Dis. 2006 Apr;6(4):226-33.<\/li>\n<li style=\"text-align: justify;\">Rahav G, Volach V, Shapiro M, Rund D, Rachmilewitz EA, Goldfarb A, et al. Severe infections in thalasssaemic patients: prevalence and predisposing factors. Br J Haematol. 2006 Jun;133(6):667-74.<\/li>\n<li style=\"text-align: justify;\">Wang SC, Lin KH, Chern JP, Lu M-Y, Jou S-T, Lin D-T, et al. Severe bacterial infection in transfusion-dependent patients with thalassemia major. Clin Infect Dis. 2003 Oct;37(7):984-8.<\/li>\n<li style=\"text-align: justify;\">Teawtrakul N, Jetsrisuparb A, Sirijerachai C, Chansung K, Wanitpongpun C. Severe bacterial infections in patients with non- transfusion-dependent thalassemia: Prevalence and risk factors. Int J Infect Dis. 2015 Oct:39:53-6.<\/li>\n<li style=\"text-align: justify;\">Ricerca B, Di Girolano A, Rund D. Infections in thalassemia and Hemoglobinopathies: Focus on therapy-Related Complications. Mediterr J Hematol Infect Dis. 2009 Dec;1(1):e2009028<\/li>\n<li style=\"text-align: justify;\">Evidence-Based management of sickle cell disease. Expert Panel Report, 2014 [Internet]. [accessed 2023 Aug 06] Available from: https:\/\/www.nhlbi.nih.gov\/sites\/default\/files\/media\/docs\/sickle-cell-disease-report%20020816_0.pdf<\/li>\n<li style=\"text-align: justify;\">Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, James AH, et al. Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members. JAMA. 2014 Sep;312(10):1033-48.<\/li>\n<li style=\"text-align: justify;\">Magnus SA, Hambleton IR, Moosdeen F, Serjeant GR, et al. Recurrent infections in homozygous sickle cell disease. Arch Dis Child. 1999 Jun;80(6):537-41.<\/li>\n<li style=\"text-align: justify;\">Hongeng S, Wilimas JA, Harris S, Day SW, Wang WC. Recurrent Streptococcus pneumoniae sepsis in children with sickle cell disease. J Pediatr. 1997 May;130(5):814-6.<\/li>\n<li style=\"text-align: justify;\">Scott LK, Grier LR, Arnold TC, Conrad SA. Serum procalcitonin concentration as a negative predictor of serious bacterial infection in acute sickle cell pain crisis. Med Sci Monit. 2003 Oct;9(10):CR426-31<\/li>\n<li style=\"text-align: justify;\">Stankovic Stojanovic K, Steichen O, Lionnet F, Bachmeyer C, Lecomte I, Avellino V, et al. Is procalcitonin a marker of invasive bacterial infection in acute sickle-cell vaso-occlusive crisis? Infection. 2011 Feb;39(1):41-5.<\/li>\n<li style=\"text-align: justify;\">Rinc\u00f3n-L\u00f3pez EM, Navarro G\u00f3mez ML, Hern\u00e1ndez-Sampelayo Matos T, Saavedra-Lozano J, de la Red YA, Hern\u00e1ndez Rup\u00e9rez B, et al. Low-risk factors for severe bacterial infection and acute chest syndrome in children with sickle cell disease. Pediatr Blood Cancer [Internet]. 2019 Jun; 66(6):e27667. Available from: https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.27667<\/li>\n<li style=\"text-align: justify;\">Mulholland EK, Simoes EA, Costales MO, McGrath EJ, Manalac EM, Gove S, et al. Standardized diagnosis of pneumonia in developing countries. Pediatr Infect Dis J. 1992 Feb;11(2):77-81.<\/li>\n<li style=\"text-align: justify;\">Strau\u00df R, Ewig S, Richter K, K\u00f6nig T, Heller G, Bauer TT. The prognostic significance of respiratory rate in patients with pneumonia: A retrospective analysis of data from 705,928 hospitalized patients in Germany from 2010-2012. Dtsch Arztebl Int. 2014 Jul;111(29-30):503-8.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Haema 2025; 16(1):30-33 \u0391\u03bc\u03b1\u03bb\u03af\u03b1 \u0391\u03bd\u03b1\u03c3\u03c4\u03b1\u03c3\u03bf\u03c0\u03bf\u03cd\u03bb\u03bf\u03c51, \u039c\u03b1\u03c1\u03af\u03b1 \u0394\u03b7\u03bc\u03bf\u03c0\u03bf\u03cd\u03bb\u03bf\u03c52 1\u0391\u0384 \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u039a\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03c4\u03b7\u03c2 \u0399\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03a3\u03c7\u03bf\u03bb\u03ae\u03c2 \u03c4\u03bf\u03c5 \u0395.\u039a.\u03a0.\u0391. \u0393\u039d\u0391 \u00ab\u039b\u03b1\u03ca\u03ba\u03cc\u00bb 2\u039c\u03bf\u03bd\u03ac\u03b4\u03b1 \u039c\u03b5\u03c3\u03bf\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u0391\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2, \u039a\u03ad\u03bd\u03c4\u03c1\u03bf \u0395\u03bc\u03c0\u03b5\u03b9\u03c1\u03bf\u03b3\u03bd\u03c9\u03bc\u03bf\u03c3\u03cd\u03bd\u03b7\u03c2 \u03a3\u03c0\u03ac\u03bd\u03b9\u03c9\u03bd \u0391\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd (\u0391\u03b9\u03bc\u03bf\u03c3\u03c6\u03b1\u03b9\u03c1\u03b9\u03bd\u03bf\u03c0\u03b1\u03b8\u03b5\u03b9\u03ce\u03bd) &amp; \u03a3\u03c0\u03ac\u03bd\u03b9\u03c9\u03bd \u039c\u03b5\u03c4\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ce\u03bd \u03bd.Gaucher \u039d\u03bf\u03c3\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd \u0393\u039d\u0391 \u00ab\u039b\u03b1\u03ca\u03ba\u03cc\u00bb &nbsp; Full PDF |<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[166],"tags":[],"class_list":["post-2030","post","type-post","status-publish","format-standard","hentry","category-haema-2025-1"],"_links":{"self":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/2030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2030"}],"version-history":[{"count":4,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/2030\/revisions"}],"predecessor-version":[{"id":2078,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/2030\/revisions\/2078"}],"wp:attachment":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2030"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2030"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}