{"id":560,"date":"2018-04-20T19:22:27","date_gmt":"2018-04-20T19:22:27","guid":{"rendered":"http:\/\/haema-journal.gr\/?p=560"},"modified":"2018-04-25T18:36:19","modified_gmt":"2018-04-25T18:36:19","slug":"biology-of-hodgkin-lymphoma","status":"publish","type":"post","link":"https:\/\/haema-journal.gr\/?p=560","title":{"rendered":"Biology of Hodgkin Lymphoma"},"content":{"rendered":"<p style=\"text-align: right;\"><em>Haema 2012; 3(3): 190-202<br \/>\n<\/em><\/p>\n<p>by Sotirios G. Papageorgiou, Vasiliki Pappa, Ioannis Dervenoulas<\/p>\n<p>Second Department of Internal Medicine, Propaedeutic, Hematology Unit, University of Athens, University General Hospital \u201cAttikon\u201d<\/p>\n<p style=\"text-align: right;\"><a href=\"http:\/\/haema-journal.gr\/PDF\/2012\/HAEMA_2012-190.pdf\" target=\"_blank\" rel=\"noopener\">Full PDF (in Greek)<\/a> | <a href=\"http:\/\/haema-journal.gr\/PDF\/2012\/HAEMA_2012-190.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-390 size-full\" src=\"http:\/\/haema-journal.gr\/wp-content\/uploads\/2018\/02\/PDF-icon.jpg\" alt=\"\" width=\"36\" height=\"36\" \/><\/a><\/p>\n<p><!--more--><\/p>\n<h5><strong>Abstract<\/strong><\/h5>\n<p style=\"text-align: justify;\">Hodgkin lymphoma (HL) is a neoplasm of lymphoid tissue, derived from mature B cells of germinal center and subdivided into classical and nodular lymphocyte predominant HL (NLPHL). HL is unique among human B cell neoplasms due to the rarity of the malignant cells, the Hodgkin and Reed- Sternberg (HRS) cells in classical HL and the lymphocyte-predominant (LP) cells in NLPHL, which usu- ally account for less than 1% of the cells in the affected tissues. Moreover, HRS cells are unique in the extent to which they show an abnormal reprogramming of B lymphocytic differentiation. This causes an abnormal and complex immunophenotype that is characterized by the expression of a wide range of antigens that are normally expressed by several distinct cell types. Deregulation of cell signaling pathways and transcription factors plays a key role in HL pathogenesis. Finally, HRS cells are found within a mixed reactive non-malignant cellular environment and interact with these nonmalignant cells in a complex fashion that appears to be essential for HRS cell survival and proliferation.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Haema 2012; 3(3): 190-202 by Sotirios G. Papageorgiou, Vasiliki Pappa, Ioannis Dervenoulas Second Department of Internal Medicine, Propaedeutic, Hematology Unit, University of Athens, University General Hospital \u201cAttikon\u201d Full PDF (in Greek) |<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[43],"tags":[],"class_list":["post-560","post","type-post","status-publish","format-standard","hentry","category-haema-2012-3"],"_links":{"self":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=560"}],"version-history":[{"count":5,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/560\/revisions"}],"predecessor-version":[{"id":998,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/560\/revisions\/998"}],"wp:attachment":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=560"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=560"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}