{"id":606,"date":"2018-04-20T21:34:49","date_gmt":"2018-04-20T21:34:49","guid":{"rendered":"http:\/\/haema-journal.gr\/?p=606"},"modified":"2018-04-25T16:37:56","modified_gmt":"2018-04-25T16:37:56","slug":"low-grade-small-b-cell-lymphomas-pathology-and-differential-diagnosis","status":"publish","type":"post","link":"https:\/\/haema-journal.gr\/?p=606","title":{"rendered":"Low-grade small B-cell lymphomas: Pathology and differential diagnosis"},"content":{"rendered":"<p style=\"text-align: right;\"><em>Haema 2013; 4(2):103-116 <\/em><\/p>\n<p>by Theodora Papadaki<\/p>\n<p>Haematopathology Department Evangelismos Hospital, Athens, Greece<\/p>\n<p style=\"text-align: right;\"><a href=\"http:\/\/haema-journal.gr\/PDF\/2013\/HAEMA_2013-103.pdf\" target=\"_blank\" rel=\"noopener\">Full PDF (in Greek)<\/a> | <a href=\"http:\/\/haema-journal.gr\/PDF\/2013\/HAEMA_2013-103.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-390 size-full\" src=\"http:\/\/haema-journal.gr\/wp-content\/uploads\/2018\/02\/PDF-icon.jpg\" alt=\"\" width=\"36\" height=\"36\" \/><\/a><\/p>\n<p><!--more--><\/p>\n<h5><strong>Abstract<\/strong><\/h5>\n<p style=\"text-align: justify;\">The broad group of small B-cell Lymphomas comprises some of the most frequently en- countered lymphomas in routine surgical pathology practice which can be subdivided into three main categories concerning their primary site of involvement: a) primary nodal and leukemic small B-cell lymphomas b) primary splenic small B-cell lymphomas and c) primary extranodal small B-cell lymphomas. The group of primary nodal and leukemic small B-cell lymphomas is highly heterogeneous with many overlapping histological and\/or immunohistochemical features. This report analyses the newly available immunohistochemical as well as molecular\/cytogenetic markers and thear value: a) in the differential diagnosis between the different entities of small B-cell lymphomas group and b) in the identification of the recently recognized precursor (early) lesions wich do not appear to represent overt lymphomas. The primary splenic small B-cell lymphomas comprise mainly distinct or provisional entities primarily involving the spleen and to a lesser extent other small B-cell lymphomas also involving primarily the lymph nodes. In this review we present the newly defined immunohistochemical and molecular\/cytogenetic characteristics of these entities helping to distinguish between: a) the different primary splenic lymphoma subtypes and b) primary splenic B-cell lymphoma from non neoplastic splenic disorders mimicking morphogically and\/or immunophenotypically lymphoma. Finally the group of primary extranodal small B-cell lymphomas, mainly represented by extranodal marginal zone lymphoma, of MALT-type, rarely includes cases of primary extranodal mantle cell lymphoma as well as primary extranodal follicular lymphoma. Given the different natural history and prognosis between the above entities a multiparametric diagnostic approach is recommended in order to differentiate between: a) these biologically different lymphoma entities; and b) lymphoma and reactive extranodal lymphoid infiltrates mimicking lymphoma.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Haema 2013; 4(2):103-116 by Theodora Papadaki Haematopathology Department Evangelismos Hospital, Athens, Greece Full PDF (in Greek) |<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45],"tags":[],"class_list":["post-606","post","type-post","status-publish","format-standard","hentry","category-haema-2013-2"],"_links":{"self":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/606","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=606"}],"version-history":[{"count":3,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/606\/revisions"}],"predecessor-version":[{"id":956,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/606\/revisions\/956"}],"wp:attachment":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=606"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=606"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=606"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}