{"id":620,"date":"2018-04-20T22:04:31","date_gmt":"2018-04-20T22:04:31","guid":{"rendered":"http:\/\/haema-journal.gr\/?p=620"},"modified":"2018-04-25T17:25:48","modified_gmt":"2018-04-25T17:25:48","slug":"current-treatment-strategy-for-mantle-cell-lymphoma","status":"publish","type":"post","link":"https:\/\/haema-journal.gr\/?p=620","title":{"rendered":"Current treatment strategy for mantle cell lymphoma"},"content":{"rendered":"<p style=\"text-align: right;\"><em>Haema 2013; 4(2):171-182 <\/em><\/p>\n<p>by Gerassimos A. Pangalis<sup>1<\/sup>, Sotirios Sachanas<sup>1<\/sup>, Theodoros P. Vassilakopoulos<sup>2<\/sup>, Maria K. Angelopoulou<sup>2<\/sup><\/p>\n<p><sup>1<\/sup> Department of Hematology, Athens Medical Center, Psychikon Branch, Athens,<br \/>\n<sup>2<\/sup>Department of Haematology, University of Athens, Greece<\/p>\n<p style=\"text-align: right;\"><a href=\"http:\/\/haema-journal.gr\/PDF\/2013\/HAEMA_2013-171.pdf\" target=\"_blank\" rel=\"noopener\">Full PDF (in Greek)<\/a> | <a href=\"http:\/\/haema-journal.gr\/PDF\/2013\/HAEMA_2013-171.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-390 size-full\" src=\"http:\/\/haema-journal.gr\/wp-content\/uploads\/2018\/02\/PDF-icon.jpg\" alt=\"\" width=\"36\" height=\"36\" \/><\/a><\/p>\n<p><!--more--><\/p>\n<h5><strong>Abstract<\/strong><\/h5>\n<p style=\"text-align: justify;\">Mantle cell lymphoma (MCL) represents approximately 3\u201310% of all non-Hodgkin lymphomas. MCL combines the \u201cdownside\u201d of both high and low grade NHL; an aggressive clinical course, but with a pattern of resistant and relapsing disease rendering it incurable to standard therapy. Recent improvement has been achieved by the successful introduction of monoclonal antibodies and dose-intensified approaches including autologous stem cell transplantation (ASCT) strategies. With the exception of allogeneic hematopoietic stem cell transplantation, current treatment approaches are non-curative and the corresponding survival curves are characterized by a delayed, but continuous decline and a median survival of 4 to 6 years. However, recently, a subset of long-term survivors have been identified with a rather indolent clinical course even after conventional treatment strategies only. Emerging strategies such as proteasome inhibitors, IMIDs, mTOR inhibitors and others show comparable efficacy to conventional chemotherapy in relapsed MCL.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Haema 2013; 4(2):171-182 by Gerassimos A. Pangalis1, Sotirios Sachanas1, Theodoros P. Vassilakopoulos2, Maria K. Angelopoulou2 1 Department of Hematology, Athens Medical Center, Psychikon Branch, Athens, 2Department of Haematology, University of Athens, Greece Full PDF (in Greek) |<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45],"tags":[],"class_list":["post-620","post","type-post","status-publish","format-standard","hentry","category-haema-2013-2"],"_links":{"self":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=620"}],"version-history":[{"count":3,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/620\/revisions"}],"predecessor-version":[{"id":963,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/620\/revisions\/963"}],"wp:attachment":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}