{"id":727,"date":"2018-04-21T22:31:17","date_gmt":"2018-04-21T22:31:17","guid":{"rendered":"http:\/\/haema-journal.gr\/?p=727"},"modified":"2018-04-25T20:31:36","modified_gmt":"2018-04-25T20:31:36","slug":"hereditary-hemochromatosis","status":"publish","type":"post","link":"https:\/\/haema-journal.gr\/?p=727","title":{"rendered":"Hereditary hemochromatosis"},"content":{"rendered":"<p style=\"text-align: right;\"><em>Haema 2016; 7(3): 305-315<\/em><\/p>\n<p>by George Papanikolaou<\/p>\n<p>School of Health Science and Education, Department of Nutrition and Dietetics, Harokopio University<\/p>\n<p style=\"text-align: right;\"><a href=\"http:\/\/haema-journal.gr\/PDF\/2016\/HAEMA_2016-305.pdf\" target=\"_blank\" rel=\"noopener\">Full PDF (in Greek)<\/a> | <a href=\"http:\/\/haema-journal.gr\/PDF\/2016\/HAEMA_2016-305.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-390 size-full\" src=\"http:\/\/haema-journal.gr\/wp-content\/uploads\/2018\/02\/PDF-icon.jpg\" alt=\"\" width=\"36\" height=\"36\" \/><\/a><\/p>\n<p><!--more--><\/p>\n<h5><strong>Abstract<\/strong><\/h5>\n<p style=\"text-align: justify;\">Hereditary hemochromotasis (H.H.) is a genetically heterogeneous disease characterized by increased iron absorption and tissue iron deposition due to mutations in genes participating in the regulation of hepcidin secretion or its receptor, ferroportin. Over the last 15 years the genetic basis of H.H. has been elucidated, allowing for an accurate genetic diagnosis for the majority of the cases. The majority of H.H. patients of northern European origin are homozygous for the C282Y mutation of the <em>HFE <\/em>gene. H.H. is a rare disease in Greece and many cases are attributed to mutations of the <em>HJV <\/em>gene associated with the severe Juvenile Hemochromatosis (J.H.) phenotype. The treatment of H.H. patients is based on phlebotomy, for removal of iron excess. \u03c4his communication reviews the pathophysiology and genetics of H.H. along with the principles of the diagnostic evaluation and therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Haema 2016; 7(3): 305-315 by George Papanikolaou School of Health Science and Education, Department of Nutrition and Dietetics, Harokopio University Full PDF (in Greek) |<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[50],"tags":[],"class_list":["post-727","post","type-post","status-publish","format-standard","hentry","category-haema-2016-3"],"_links":{"self":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/727","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=727"}],"version-history":[{"count":3,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/727\/revisions"}],"predecessor-version":[{"id":1116,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=\/wp\/v2\/posts\/727\/revisions\/1116"}],"wp:attachment":[{"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=727"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/haema-journal.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=727"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}